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How to use the tool
- Total Cholesterol: type your lab value, e.g., 185 mg/dL or 5.0 mmol/L.
- HDL Cholesterol: add your “good” cholesterol, e.g., 62 mg/dL or 1.6 mmol/L.
- Triglycerides: enter the level shown on your report, e.g., 135 mg/dL or 1.3 mmol/L.
- Units: pick mg/dL (USA) or mmol/L (most of Europe).
- Calculation Method: choose Friedewald, Iranian, or Anandaraja to suit your profile (details below).
- Calculate: press the button—your LDL number and risk category appear instantly.
Quick-Facts
- Optimal LDL target: < 100 mg/dL (Grundy et al., 2019).
- Friedewald formula unreliable when triglycerides > 400 mg/dL (MedlinePlus, https://medlineplus.gov/lab-tests/lipid-panel).
- 1 mmol/L cholesterol = 38.67 mg/dL (CDC, 2020).
- Direct LDL test costs ≈ US $30–70 in U.S. outpatient labs (Healthcare Bluebook, 2023).
Formulas and worked examples
1. Friedewald (standard)
$$LDL = TC – HDL – rac{TG}{5}$$
- Example: TC 190 mg/dL, HDL 48 mg/dL, TG 125 mg/dL.
- Calculation: 190 – 48 – 25 = 117 mg/dL.
2. Iranian (high triglycerides)
$$LDL = rac{TC}{1.19} + rac{TG}{1.9} – rac{HDL}{1.1} – 38$$
- Example: TC 250 mg/dL, HDL 42 mg/dL, TG 410 mg/dL.
- Calculation: 210.1 + 215.8 – 38.2 – 38 = 349.7 mg/dL.
3. Anandaraja (alternative)
$$LDL = 0.9 \times TC – 0.9 \times HDL – 0.1 \times TG$$
- Example: TC 175 mg/dL, HDL 55 mg/dL, TG 145 mg/dL.
- Calculation: 157.5 – 49.5 – 14.5 = 93.5 mg/dL.
FAQ
What is LDL cholesterol?
LDL carries cholesterol to tissues; excess promotes arterial plaque and heart disease (Heart Foundation, https://www.heart.org).
Which formula should you pick?
Use Friedewald when TG ≤ 400 mg/dL; switch to Iranian or direct testing if TG exceeds this limit (MedlinePlus, link above).
How often should you test LDL?
Adults with average risk test every 4–6 years; high-risk patients check annually (Grundy et al., 2019).
Can you calculate LDL without fasting?
Yes; non-fasting panels give similar LDL except when TG > 400 mg/dL (Nordestgaard et al., 2016).
How do mg/dL and mmol/L convert?
Cholesterol: multiply mmol/L by 38.67 to get mg/dL; divide mg/dL by 38.67 for mmol/L (CDC, 2020).
Why choose direct LDL testing?
Direct assays bypass formula limits, giving accurate results in high TG, diabetes or pregnancy (Quest Diagnostics, 2022).
What lowers LDL most effectively?
Statins cut LDL 30–50 %; replacing saturated fat with unsaturated reduces ~10 % (Santos et al., 2020).
Does exercise impact LDL?
150 minutes of moderate aerobic activity weekly can drop LDL by 5–10 % (CDC, 2021).
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